Gepabene to restore the liver. Gepabene - instructions for the use of tablets, indications, composition, side effects, analogues and price of Karsil or Gepabene

Produced on the basis of natural ingredients. It is used in the treatment of various liver pathologies, maintaining its condition and restoring damaged organ cells. The drug is also prescribed for problems that arise in the biliary tract. Due to its high efficiency and safety, the drug is widely used in medical practice.

Gepabene is a hepatoprotector that is used in the treatment of various liver pathologies.

International non-proprietary name

Milk thistle fruit (cardui mariae fructus)

Flamboyant medicinal herb (fumariae herba)

ATC and registration number Gepabene

ATX code: A 05BA.

Registration number: P N012369/01.

Pharmacotherapeutic group Gepabene

Choleretic agents of plant origin.

Mechanism of action

The drug acts as a hepatoprotective and choleretic drug.

Pharmacodynamics of the drug is determined by its active ingredients:

Extract of fumes officinalis. The main substance present in the extract is the alkaloid fumarin, under the influence of which the amount of bile returns to normal. Its outflow is also normalized, the spasm of the gallbladder is relieved.
Milk thistle fruits. In this extract, the main substance is silymarin. Thanks to this component, the drug has the ability to restore liver cells. Under the action of silymarin and its isomers, the production of proteins improves.

The release form of the drug is capsules.

How to take Gepabene

Capsules should be swallowed whole and should not be chewed or split in half. Half a glass of water will help ease the process of swallowing.

Before or after meals

It is better to take the medicine not before or after meals, but during breakfast, lunch or dinner. So you can achieve the best pharmacological effect.

Indications for use

The doctor selects several drugs indicated for this disease, and prescribes a comprehensive course of treatment. Such therapy is also indicated after.

Another indication for the appointment of a hepatoprotector is the penetration of toxic substances into the liver tissue. Damage to the organ can be caused by various reasons - the intake of low-quality products, the use of alcohol, poor environmental conditions, etc.

Contraindications

The drug has few contraindications, but before starting treatment, it is better to consult a doctor.

The drug is not prescribed to patients who have intolerance to any component that is part of the drug.

In acute inflammatory processes developing in the bile ducts, the drug is also contraindicated.

Gallstone disease is also a contraindication to taking capsules.

Method of application and dosage

Capsules should be taken orally.

For an adult, 3 capsules of Gepabene per day are enough - one at a time for breakfast, lunch and dinner.

The dosage is selected by the attending physician, taking into account the results of the examination of the patient. In accordance with the instructions for use, an adult needs 3 capsules per day - one at a time during breakfast, lunch and dinner.

Depending on the state of health, the daily dose can be increased to a maximum of 6 capsules per day. Multiplicity of reception - 3-4 times within 24 hours.

special instructions

During treatment, the patient must follow all the doctor's recommendations: take prescribed medications in the prescribed dosage, follow the diet recommended by the doctor.

During pregnancy and lactation

A pregnant woman can take the drug only as directed by a doctor. This also applies to women who are breastfeeding their babies.

In childhood

In pediatric practice, the drug is not used.

In old age

Old age is not a contraindication to taking capsules, but the patient should consult a doctor before starting treatment.

For impaired liver function

For impaired renal function

The instructions for the drug do not indicate that it is contraindicated in patients with impaired renal function, so the decision to treat such patients should be made by the doctor.

Side effects

Against the background of taking the medicine, an increase in diuresis is possible. In rare cases, a laxative effect and allergic reactions occur.

Impact on vehicle control

The drug does not affect the concentration of attention and the speed of psychomotor reactions, so driving a car or engaging in hazardous activities is not prohibited.

Overdose

Cases of overdose have not been registered. If the patient accidentally took a large dose of the drug, then he should consult a doctor.

drug interaction

In medical practice, there are no cases of interaction of Gepabene with other medications.

Alcohol compatibility

During the period of therapy, you should stop drinking alcohol.

Manufacturer

Merkle GmbH, Germany

Terms of dispensing from pharmacies

The drug belongs to prescription drugs.

How much does it cost in Russia and Ukraine

The cost of the drug in Russian pharmacies is about 450 rubles. per pack of 30 capsules. The price of the same package in Ukrainian pharmacies is about 170 UAH.,. Approximately in the same price category as Gepabene, Hofitol, Odeston, Ursosan are offered.

The most popular analogues are Essentiale Forte N.

Which drug is most suitable for the patient, the doctor will tell. It will not be possible to independently decide what is better to use.

Gepabene is a good hepatoprotector and choleretic agent. Its active ingredients are natural plant extracts. It contains fumarin extract, a plant rich in the alkaloid fumarin. Taking the drug has a choleretic effect, reduces the high degree of tone of the biliary tract, lowers the tone of the sphincter of Oddi, normalizes the composition and amount of bile produced by the body. As a result, the outflow of bile into the intestine improves.

Composition and form of release

The drug is available in the form of soft brown hard gelatin capsules. Inside contains a powder, the color of which can be either orange-brown or light brown with light patches.

The product contains natural herbal extracts:

dry extract of the herb fume herb officinalis;
dry extract of milk thistle fruits.

Additional components of the drug Gepabene: corn starch, microcrystalline cellulose, silicon dioxide, magnesium stearate, talc, macrogol 6000, copolyvidone, titanium dioxide, purified water, gelatin, black iron oxide, red iron oxide, yellow iron oxide.

pharmachologic effect

Instructions for use indicate that the composition of the drug contains silymarin, which is part of the extract from the fruits of milk thistle, it TV, in turn, helps to bind and remove free radicals from the body. It is due to its presence that a membrane-stimulating and regenerating effect on liver cells is manifested. The active substances of the drug Gepabene, being in an optimally balanced ratio, affect all these processes, restoring the functioning of the liver.

Properties of fumarin in the composition of the product:

has a choleretic effect;
reduces the tone of the biliary tract and the sphincter of Oddi;
regulates the composition of bile and the formation of its quantity;
normalizes the motor function of the gallbladder and ducts.

Silymarin and its isomers in the composition of the Hepabene preparation, such as silibanan, silicristin and silidianin, improve the protein-forming function of the liver in difficult cases, when acute or chronic forms of liver pathologies were found in patients. Silymarin dissolves in water only in a small proportion and at the same time forms salts with alkalis due to acidic properties. Silymarin metabolites such as sulfates and glucuronides are excreted in the bile. When it enters the intestine, it can be absorbed again in the form of silymarin broken down by intestinal bacteria, due to this action, the drug is recirculated.

Indications for use of Gepabene

dyskinesia (dysmotility) of the biliary tract;
dyskinesia of the bile duct after surgery to remove the gallbladder;
chronic hepatitis;
toxic hepatitis;
cirrhosis of the liver;
fatty degeneration of the liver.

Side effects of the remedy

The medicine is very well tolerated by the body and all this is due to the natural ingredients. In rare cases, unwanted manifestations may occur:

laxative effect;
increased urination;
allergic manifestations (rash).

Contraindications

Capsules are not recommended for use if the patient has a particular sensitivity to the components of the drug. Also, Gepabene should not be taken by children under 6 years of age and patients with acute pathology of the biliary tract and liver.

Instructions for use

Method and dosage of capsules

Capsules must be taken orally, without chewing or biting, drinking plenty of water. The standard dosage is 1 capsule three times a day. If the patient has severe pain at night, then you can additionally take another capsule before bedtime. But it is worth remembering that the daily norm of the remedy should not exceed 6 capsules, which will be divided into several doses.

Elderly patients do not need to adjust the dose of the drug.

The course of treatment with the drug is long for at least three months, only in this case you can get the desired result from therapy.

Gepabene for children

During pregnancy and lactation

There is no data on how the capsules affect the fetus of a pregnant woman. Many doctors do not recommend taking risks and do not use the medicine in the treatment of pregnant and lactating women. But there is also such information that the drug was used in the treatment of women expecting the birth of a child and did not cause harm. The decision on the use of the drug should be made by the doctor, who will monitor all changes in the patient's body.

special instructions

Instructions for use notes that elderly patients do not need to adjust the dose of Gepabene. In view of the fact that taking the drug Gepabene can lead to an estrogen-like effect, the use of silymarin in high doses is not recommended for patients who have a hormonal imbalance (endometriosis, uterine fibroids, carcinoma of the breast, ovary and uterus, prostate carcinoma). Such patients, before starting therapy, you need to consult a doctor.

In cases where the patient is at risk of developing jaundice, then you need to consult a doctor about adjusting the dose of Gepabene. With the simultaneous use of Gepabene, which contains silymarin and oral contraceptives or drugs used for estrogen replacement therapy, it is possible to reduce the effect of the latter.

Gepabene enhances the effect of certain drugs, including diazepam, alprazolam, ketoconazole, lovastatin, vinblastine, fexofenadine, clopidogrel, warfarin, and all this happens due to the inhibition of the cytochrome P450 system.

Domestic and foreign analogues

There are a huge number of drugs that do an excellent job with diseases of the liver and biliary tract. But among them there are those that are not suitable for all patients, causing side effects, so if suddenly the drug Gepabene did not fit, you should not immediately run to the pharmacy and take the first of the proposed drugs on your own, it is better to seek help from your doctor. Among the analogues of Gepabene, the following can be noted: Antral, Gepalin, Geparsil, Gepafil, Gepaforte; Ursodeoxycholic acid; Ursodex; Ursoliv; Ursor; Ursosan; Ursofalk; Phosfonciale; Hepabos; Choludexan; Exhol; Erbisol; Essentiale N; Essentiale forte N; Essential phospholipids; Essliver and many others.

Price in pharmacies

The price of Gepabene in different pharmacies can vary significantly. This is due to the use of cheaper components and the pricing policy of the pharmacy chain.

Read the official information about the drug Gepabene, the instructions for use of which include general information and a treatment regimen. The text is provided for informational purposes only and is not a substitute for medical advice.

Approximate price of Gepabene bl/N10x3 is about 300 rubles.

HEPABENE - hepatoprotector with choleretic and antispasmodic action. Normalizes liver function; possesses antioxidant, membrane-stabilizing and reparative properties. Reduces the degree of fatty degeneration of the liver, activates the metabolism in the liver cells, promotes the regeneration of hepatocytes. Normalizes the secretion of bile and motility of the biliary tract with their dyskinesia; facilitates the flow of bile into the intestines. It is used in the treatment of chronic hepatitis, liver, fatty liver, toxic liver damage, biliary dyskinesia, conditions after cholecystectomy.

Latin name:
HEPABENE / HEPABENE.

Composition and form of release:
Gepabene capsules 30 or 100 pcs. packaged.
1 capsule of Gepabene contains: extract of milk thistle 70-100 mg (Fructus Silybi mariani) with a standardized amount of flavonoids (50 mg of silymarin, of which at least 22 mg of silibinin), as well as an extract of 275 mg of fumes (Fumaria officialis), containing at least 4.13 mg protopine alkaloid.

Properties / Action:

Gepabene normalizes liver function in various acute and chronic pathological conditions.
The therapeutic properties of Gepabene are determined by the optimal combination of the hepatoprotective effect of the milk thistle extract and the normalizing bile secretion and biliary tract motility of the influence of the pharmacy fumes.
Milk thistle fruit extract. The plant flavonoid substance isolated from milk thistle fruits and milky juice contains a complex of isomeric compounds of polyhydroxyphenolchromanones, the main of which are silymarin, silibinin, silidiadin and silychristin. The hepatoprotective effect of silymarin is due to its antioxidant, membrane-stabilizing and reparative properties. Silymarin exhibits a hepatoprotective effect in acute and chronic intoxications. Excessive accumulation of free radicals and products of lipid peroxidation is one of the leading pathogenetic mechanisms of hepatocyte damage under the action of toxins of exogenous and endogenous origin, ultimately leading to damage to the lipid layer of cell membranes and cell destruction. Silymarin prevents the accumulation of lipid hydroperoxides, thereby reducing the degree of damage to liver cells. Significantly reduces the elevated level of transaminases in the blood serum, reduces the degree of fatty degeneration of the liver. By stabilizing the cell membrane of hepatocytes, it slows down the entry of toxic metabolic products into them. Silymarin activates the metabolism in the cell, resulting in the normalization of protein-synthetic and lipotropic functions of the liver, promotes the regeneration of hepatocytes. Improving the immunological reactivity of the body.
Extract of fumes officinalis (pharmacy). The main active ingredient of fume medicinal is a derivative of fumaric acid - the alkaloid protopine. It normalizes both too weak and increased bile secretion, relieves spasm of the sphincter of ODDI, normalizes the motor function of the biliary tract with their dyskinesia, both in hyperkinetic and hypokinetic types. Effectively restores the drainage function of the biliary tract, preventing the development of bile stasis and the formation of stones in the gallbladder, facilitates the flow of bile into the intestines.

Pharmacokinetics:
Silymarin is practically insoluble in water. Due to its slightly acidic properties, it can form salts with alkaline substances. More than 80% of the drug is excreted in the bile in the form of gluconorides and sulfates. As a result of cleavage by the intestinal microflora, up to 40% of the silymarin excreted in the bile is reabsorbed again, as a result of which the enterohepatic circulation (recirculation) is created. The drug binds weakly to plasma proteins. After a single oral administration, plasma concentration reaches a maximum after 30 minutes. The maximum excretion with bile is reached after 2 hours. The half-life is 5.5 - 6 hours.

Indications :
Gepabene is used as part of the complex therapy of the following diseases:
biliary dyskinesia of the hyperkinetic and hypokinetic type, especially combined with liver damage;
chronic hepatitis (particularly subacute, chronic persistent or chronic active form);
cirrhosis of the liver;
fatty degeneration of the liver;
toxic-metabolic lesions of the liver, including xenobiotics;
condition after cholecystectomy surgery (postcholecystectomy syndrome).

Dosage and administration:
Gepabene capsules should be taken orally, during or after a meal, without chewing, with a small amount of water. Gepabene is usually prescribed 1 capsule 3 times a day.
With nocturnal pain syndrome, it is recommended to take an additional 1 capsule at bedtime.
The daily dose of Gepabene can be increased to 6 capsules (2 capsules 3 times a day).

Overdose :
To date, cases of overdose of the drug Gepabene have not been reported.
Treatment: no special measures other than drug withdrawal and routine medical supervision are required.

Contraindications:
acute and subacute inflammatory diseases of the liver and biliary tract, acute cholecystoangiocholitis with damage to the intrahepatic bile ducts;
individual intolerance (including a history of hypersensitivity) to the components of Gepabene.

Use during pregnancy and lactation:
The use of Gepabene during pregnancy and lactation (breastfeeding) is possible only under strict indications and under the close supervision of the attending physician. Data on the adverse effects of the drug Gepabene on the fetus or newborn are not available.

Side effects:
Possible: laxative effect (diarrhea), increased diuresis, allergic reactions (urticaria, itching), weakness.

Special instructions and precautions:
During the period of treatment with Gepabene, patients must strictly observe the regimen prescribed by the doctor, diet, other medicinal prescriptions, and refrain from drinking alcohol.

drug interaction:
The drug interaction of the drug Gepabene has not yet been described.

Storage conditions:
Keep out of the reach of children, at a temperature not exceeding 25°C.
Shelf life: 5 years.

Gepabene is a hepatoprotector, a choleretic drug based on components of plant origin.

Release form and composition

Gepabene capsules are made hard, gelatinous, light brown. The contents of the capsules are powder, the color of which varies from orange-brown to light brown, with light patches.

The active substances of the drug are the following herbal ingredients:

Dry extract of herb fumes officinalis 275, 1 mg (including protopin 4.13 mg);
Dry extract of milk thistle fruits 83.1 mg (including silymarin 50 mg, silibinin 22 mg).

Auxiliary components of the drug are: corn starch, microcrystalline cellulose, silicon dioxide, magnesium stearate, talc, macrogol 6000, copolyvidone, titanium dioxide, purified water, gelatin, black iron oxide, red iron oxide, yellow iron oxide.

In blisters of 10 capsules, 3 blisters in cardboard boxes.

Indications for use

According to the instructions, Gepabene is indicated for use as part of the complex treatment of the following diseases:

Chronic hepatitis (including chronic persistent, subacute and chronic active forms);
Biliary dyskinesia, including after cholecystectomy (surgical intervention to remove the gallbladder);
Cirrhosis of the liver;
Fatty degeneration of the liver;
Toxic-metabolic lesions of the liver, including xenobiotics;
Chronic toxic liver damage.

Contraindications

According to the instructions, Gepabene should not be used in the following cases:

Hypersensitivity to the active or auxiliary components of the phytopreparation, as well as to other plants of the Compositae family;
Acute poisoning of a different nature;
Cholelithiasis;
Cholangitis or acute hepatitis;
Acute inflammatory diseases of the liver and biliary tract;
Obstruction of the bile ducts.

Method of application and dosage

Phytopreparation Gepabene is intended for internal use. Capsules are taken after meals and washed down with half a glass of water. The standard dosage of the drug is 1 capsule three times a day.

If the patient experiences pain at night, it is recommended to additionally use Gepabene at bedtime in the amount of 1 capsule.

The daily dose of the drug at the discretion of the attending physician may be increased to 6 capsules, divided into several doses. The duration of therapy is determined by the attending physician on an individual basis, and depends on the type of disease, the severity of its course and the effectiveness of therapy.

Elderly patients do not need to adjust the dose of the drug.

Side effects

The use of Gepabene in most cases is well tolerated by patients. If the recommended dosage is observed, the phytopreparation does not cause side effects. In rare cases, such negative reactions from various systems of the body's vital activity are not excluded:

Digestive system: nausea, vomiting, diarrhea, dyspepsia, heartburn;
Urinary system: increased diuresis;
Skin and subcutaneous tissue: alopecia (baldness);
Cardiovascular system: sudden feeling of heat in the face and upper part of the body;
Vestibular apparatus: dizziness, sweating, changes in blood pressure, loss of balance, disorder of coordination of movement.

In addition to the above side effects, Gepabene can cause the development of allergic reactions in the form of urticaria, rashes, itching on the skin, due to hypersensitivity to the components of the drug.

special instructions

The composition of Gepabene capsules includes silymarin, which is capable of exerting an estrogen-like effect, therefore, the phytotherapeutic drug is recommended to be used with caution in patients with hormonal disorders and diseases such as carcinoma of the prostate, ovaries, uterus, breast, uterine fibroids, endometriosis, etc.

In the case of the use of Gepabene in excessive dosages, the development of abdominal pain in the abdomen and diarrhea is theoretically possible. In this case, the patient should stop therapy with the drug and consult a doctor.

Due to the inhibition of the cytochrome P450 system, Gepabene is able to enhance the effect of drugs containing vinblastine, diazepam, lovastatin, clopidogrel, warfarin, ketoconazole, alprazolam, fexofenadine.

Women taking estrogen replacement therapy or oral contraceptives should be aware that silymarin, which is part of Gepabene, may reduce the effectiveness of these drugs.

Analogues

According to the similarity of the mechanisms of action and belonging to the same pharmacological group, the following drugs can be attributed to Gepabene analogues: Arnica tincture, Allohol, Artichol, Artichoke extract, Artibel, Berberine, Artichoke Sandoz, Barberry ordinary leaves tincture, Immortelle Sandy flowers, Tanacehol, Tansy flowers, Salvat, Gepatsinar, Corn columns with stigmas, Convaflavin, Holos, Holosas, Liobil, Low-vitamin rosehip fruits, Cholagol, Olimetin, Odeston, Cholagogue collection No. 2, Gepatsinar, Bonjigar, Hofitol, Cynarix, Rafacholin C, Cholemax, Flamin, Tsikvalon.

Last update of the description by the manufacturer 09/30/2016

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Active substance:

ATX

Pharmacological groups

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Compound

Capsules	1 caps.
active substances:
fumes medicinal herb dry extract	275.1 mg
(corresponding to 4.13 mg total fumaric alkaloids expressed as protopine)
milk thistle fruit extract dry	83.1 mg
(corresponding to 50 mg of silymarin, including at least 22 mg of silybin)
Excipients: MCC - 80.1 mg; corn starch - 20.1 mg; talc - 8.4 mg; macrogol 6000 - 4.5 mg; copolividone - 4.5 mg; magnesium stearate - 2.1 mg; silicon dioxide - 2.1 mg
capsule shell: gelatin - 79.94 mg; iron oxide yellow - 0.67 mg; iron oxide red - 0.15 mg; iron oxide black - 0.04 mg; titanium dioxide - 1.29 mg; purified water - 13.92 mg

Description of the dosage form

Hard gelatin capsules, size 0, light brown. The contents of the capsules are an orange-brown to light brown powder, with lighter inclusions.

pharmachologic effect

pharmachologic effect- hepatoprotective, choleretic.

Pharmacodynamics

Gepabene ® is a combination preparation of plant origin, containing fume extract and milk thistle extract.

The fumarin alkaloid extract normalizes the amount of secreted bile, relieves spasm of the gallbladder and bile ducts, facilitating the flow of bile into the intestines.

Milk thistle fruit extract contains silymarin, which exhibits a hepatoprotective effect in acute and chronic intoxications, binds free radicals and toxic substances in the liver tissue, has antioxidant and membrane stabilizing activity, stimulates protein synthesis, and promotes the restoration of liver cells.

Gepabene ® normalizes liver function in various chronic pathological conditions.