Especially with degenerative-dystrophic changes in the connective and cartilaginous tissue, as well as bone damage. They help not only stop the progression of diseases, but also stimulate the speedy recovery of tissues, which reduces the risk of complications.

Chondroprotectors are a group of drugs whose action is aimed at restoring the normal amount of intra-articular fluid, cartilage and connective tissue of articular joints. Depending on the generation of funds, medicines of 1,2 and 3 generations are isolated.

The first generation is represented by herbal preparations. They contain extracts from medicinal plants, as well as cartilage of fish and animals, have a gentle effect on the body and help restore cartilage tissue. In addition, funds rarely have a negative impact on internal organs and systems.

The second generation of medicines in its composition contains not only chondroitin and glucosamine, but also the necessary hyaluronic acid. All these components are normally found in the human body and ensure the normal functioning of the musculoskeletal system.

The third generation is represented by the most effective medicines, which contain a large number of chondroitin sulfate and hydrochloride. Means are used quite often, have a complex effect on the body.

Experts distinguish several groups of funds depending on the composition:

Regardless of the composition of the agent, it has an effect on the joint, stimulates the production of synovial fluid, promotes the rapid division of cartilage cells and improves microcirculation in the affected area.

Chondroprotectors for joints can be divided depending on the form of their release:

Release form	Peculiarities
Capsules, tablets, powders for oral solution	Typically, drugs in this form are prescribed at the initial and progressive stages of arthrosis, arthritis and other disorders. However, the patient should not have serious complications. The action of medicines begins after penetration into the digestive tract, which is not always convenient, because in diseases of the stomach or intestines, the active components are absorbed somewhat worse, which makes the treatment less effective and longer. It is also worth noting that the duration of the therapeutic course when using oral forms is at least 3 months, and in most cases reaches 6-8 months. The first results appear after 4-6 weeks, which is considered a rather long period, especially with an exacerbation of the disease.
Solutions for parenteral administration	Means in the form of solutions are usually administered intramuscularly, they are highly effective. In this case, the course of treatment does not exceed 4 weeks, and the first result can be observed after 7-10 days of treatment. This form is considered more preferable for the advanced form of the disease of the joints and spinal column, as it helps to quickly obtain a therapeutic effect. An additional advantage is parenteral administration, in which the active ingredients enter the bloodstream immediately, bypassing the digestive tract.
Joint fluid substitutes	This form of chondroprotectors is considered the most effective, but may not always be used. Articular fluid substitutes are prescribed for severe chronic arthrosis without pronounced signs of inflammation. They help restore mobility, relieve pain, and stimulate tissue repair. Means can be used no more than 1 time in 7 days, some injections are made no more than 5-6 times a year, since more frequent use can provoke complications. The main advantage of the funds is considered to be an almost instantaneous effect, which can be felt within 1-2 hours after administration.
Ointments, gels and creams	External forms of drugs that also have therapeutic properties, but are used more often as part of complex therapy using systemic drugs. Medicines contain the same active substances and have a similar effect, but in most cases it is less pronounced, and the effect is noticeable only after 10-14 days of regular use.

Each form of release has its advantages and disadvantages, so the decision to prescribe a particular drug is made by the doctor.

Top 10 drugs from the pharmacy

Chondroprotectors can be found on the shelves of every pharmacy. They are used not only for joints, but also as a prophylactic for injuries and pathologies of the spinal column. There are tools that are considered the most effective.

Teraflex

Combined chondroprotector based on glucosamine and chondroitin. It contains these components in large quantities and is often used for chronic arthritis, arthrosis, and osteochondrosis. The active ingredients contribute to the normalization of the amount of synovial fluid, help restore the cartilage layer in the joint and prevent the development of inflammation.

The drug is available in the form of gelatin capsules, which must be taken orally 1 piece 3 times a day. Duration of treatment - from 3 months to six months. The remedy is considered potent, but is not prescribed for lactating and pregnant women, children under 15 years of age and patients with intolerance to its components. The price of the drug starts from 315 rubles. for 30 capsules.

Mukosat

Chondroprotector based on chondroitin sulfate, which has a pronounced effect, restores cartilage tissue, eliminates joint pain and improves mobility. It is prescribed for patients with osteochondrosis and severe osteoarthritis of varying severity.

The drug is available in the form of tablets, capsules and solution for parenteral, i.e. intramuscular injection. The latter form of release is considered the most effective, especially for lesions. digestive tract when capsules and tablets are not digested.

The solution is administered to the patient daily in an amount of 1 or 2 ml per muscle. The duration of the therapeutic course is 10-30 days. Capsules and tablets should be consumed for at least 3 months in a row in the amount of 2 pieces per day, washed down with plenty of water.

The drug is contraindicated during pregnancy, lactation, with intolerance to its components. The price of the medicine ranges from 250-600 rubles. depending on the form of release and dosage.

Don

Chondroprotectors for joints in powder form are popular. The drug Dona contains the substance glucosamine sulfate.

The component has several pharmacological properties:

1. Painkiller.
2. Anti-inflammatory.
3. Stimulates tissue regeneration.
4. Normalizes the amount of synovial fluid.
5. Improves mobility in the joint.

The tool is available not only in the form of a powder, but also in the form of a solution for injection into the muscle and tablets for oral administration. The solution is administered 1 time per day in the amount of 1 ampoule, the duration of the course is from 10 to 30 days.

Tablets should be taken 1 piece 3 times a day. The powder dissolves in a small amount of water, 1 sachet is needed at one time, repeat it daily.

The duration of treatment with oral forms is from 1 to 3 months. The drug is potent and effective, but is not used for patients under 12 years of age, during lactation and pregnancy. It is contraindicated in case of intolerance to the main component. The price of the medicine starts from 1200 rubles. per package, depends on the form of release and the number of ampoules, bags or tablets.

Alflutop

The drug is in the form of a solution for injection deep into the muscle. The composition contains a bioactive concentrate of several types of marine fish. It has chondroprotective properties, stimulates the body's own defenses, which accelerates the regeneration of cartilage and connective tissue of the joint.

It is considered a fairly potent drug. The course of treatment consists of 10-35 injections, which are done daily. The drug is contraindicated in pregnancy and lactation, under the age of 18, with intolerance to its active component. The price of the medicine starts from 1500 rubles. and depends on the region of distribution.

Artra

Combined American drug in the form of tablets, which contains glucosamine and chondroitin. It has unique therapeutic properties, quickly eliminates signs of inflammation in the joint, normalizes mobility, eliminates pain. Additionally, the drug stimulates the division of cartilage cells, which contributes to its restoration.

A potent medication is prescribed for chronic organ pathologies, after injuries or during an exacerbation. The daily dosage is 2 tablets, they must be taken 4 weeks in a row.

After that, the dosage is reduced to 1 tablet per day and continued to be taken for 3-6 months. The drug is not used during pregnancy, lactation, with allergies to its components. It is also contraindicated in patients under 15 years of age. The price of the product is approximately 800-900 rubles.

KONDRONova

Chondroprotector, which has an effect due to the content of glucosamine and chondroitin. Helps prevent the progression of degenerative-dystrophic diseases, eliminates pain, improves joint mobility. A medication is produced in the form of capsules and ointments for external use, it is considered potent.

Capsules should be taken for at least 3 consecutive months, 2 pieces 2 times a day. The ointment is used externally, it must be applied in a thin layer on the affected joints, rubbed in, repeat the procedure 2-3 times a day for 4 weeks.

Medicines are not used in case of intolerance to their components. Capsules are contraindicated during pregnancy, lactation and under the age of 18 years. The price of capsules is 350-550 rubles, the ointment can be purchased for 300 rubles.

Gialgan Phidias

Chondroprotectors for joints in liquid form are used in most cases with advanced arthrosis and other pathologies. Hyalgan Phidias is a substitute for intra-articular fluid and is available in the form of a viscous solution packaged in disposable sterile syringes.

Each syringe contains 1 dose of the drug. The remedy belongs to potent medicines and is prescribed only by a doctor.

The medicine is injected directly into the joint bag 1 time in 7 days. In this case, no more than 5 doses are administered. It is allowed to repeat the course no earlier than after 6 months. The tool eliminates pain in the joint, stimulates metabolic processes, softens the friction of the heads of the bones.

In addition, it accelerates regeneration processes, improves mobility and relieves inflammation. The procedure is carried out only in a hospital by a specialist, sometimes injections are done on an outpatient basis.

However, it is worth noting that the introduction is carried out by a doctor, and after the manipulation, the patient is under observation for 1-3 hours. At this time, it is strongly not recommended to load the joint into which the agent was introduced. For the next few days, you must adhere to a sparing regimen so as not to provoke complications.

The drug is not administered with the development of purulent bursitis, during lactation and pregnancy. It is also contraindicated in patients with hepatic and renal insufficiency, under the age of 18 years. The price of 1 syringe reaches 4000 rubles.

Chondrolon

A drug from the group of chondroprotectors that has a therapeutic effect due to the content of chondroitin sulfate. It has anti-inflammatory, decongestant and analgesic properties.

Additionally stimulates the regeneration of cartilage and the production of intra-articular fluid. Despite the effectiveness, the drug cannot be classified as potent, since it is not able to significantly improve the patient's condition with advanced forms of the disease.

The product is available in the form of a lyophilisate in ampoules. The powder dissolves in 1 ml of water for injection and is administered intramuscularly 1 time in 2 days. The course consists of 15-35 injections, depending on the severity of the patient's condition.

The drug is not prescribed to lactating and pregnant women, children under 18 years of age, patients with a tendency to bleeding or blood clots. The price of a package of 10 ampoules starts at 120 rubles.

Chondroitin gel

One of the most popular and affordable outdoor products. The composition contains a large amount of chondroitin sulfate, which helps to relieve inflammation, facilitate movement and stimulate tissue repair.

The remedy is available in the form of a gel, which should be used for 3-4 consecutive weeks, applied in a thin layer and rubbed into the affected areas 2-3 times a day. The drug does not have a strong effect, therefore, it is most often prescribed as an adjuvant as part of a complex treatment with systemic medicines.

Contraindication to use is lactation and pregnancy, as well as an allergy to any of the components of the drug. In addition, experts do not recommend using it if there is a wound, a crack or an area with rashes in the area of ​​\u200b\u200bthe intended application.

With exacerbation of psoriasis, eczema or chronic dermatitis, the medication is also not prescribed, since it can provoke complications. The price of the gel starts from 80 rubles. and depends on the region of distribution.

Chondrogard

Chondroprotector in the form of a solution for injection into the muscle. Chondroitin is present as an active ingredient in the composition. The medicine is used at different stages of arthrosis, osteochondrosis and during the rehabilitation period after joint injuries.

When using the solution, mobility in the affected joint improves, pain and stiffness are eliminated, and the development of inflammation is also prevented. The solution is administered intramuscularly in an amount of 1 ml per day.

The first 4 injections are done 1 time in 2 days. After that, the dosage can be increased to 2 ml per day. The number of injections is 20-35, depending on the degree of neglect of the condition.

The drug is not used in the following cases:

1. Intolerance to the main active ingredient.
2. Tendency to internal bleeding.
3. Thrombophlebitis at the initial or advanced stage.
4. The period of lactation and childbearing.
5. Age up to 18 years.

The drug is considered potent, quickly improves the patient's condition and, if used correctly, rarely provokes complications. Its cost starts from 700 rubles. for 10 ampoules.

Chondroprotectors are the most preferred means for joints with the development of degenerative-dystrophic changes. They help not only eliminate the symptoms of diseases, but also improve the condition of cartilage, connective, bone tissue. A doctor should prescribe medications, which will reduce the risk of complications.

Article formatting: Vladimir the Great

Video about chondroprotectors

Side effects about chondroprotectors:

Chondroprotectors are long-acting drugs that nourish cartilage tissue, slow down its destruction and contribute to its restoration.

Chondroprotectors are prescribed for diseases of the joints associated with the destruction of cartilage.

These include arthrosis, arthritis and periarthritis, osteochondrosis, dystrophic changes in articular cartilage, periodontal disease, etc. They are also prescribed during the recovery period after joint surgery.

There are two types of classification of chondroprotectors - by composition and by generations (the time of introduction into medical practice).

According to the first sign, drugs are divided as follows:

• Preparations that include chondroitin sulfate (chondroitin sulfuric acid). It is the main building material for joints. It prevents further destruction of cartilage tissue, stimulates the production of interarticular fluid, and reduces the intensity of pain. The main drugs based on it are Chondroxide, Chondrolone, Mukosat, Artron.
• Preparations consisting of their bone marrow and cartilage of animals - Alflutop, Rumalon.
• Mucopolysaccharides - Arteparon.
• Preparations based on glucosamine, which is a natural compound that helps restore the functions of cartilage tissue, improves its elasticity and inhibits the development of degenerative processes (Artron flex, Dona).
• Preparations with a complex composition - Teraflex, Artron complex.
• A drug that has both chondroprotective and anti-inflammatory properties - Artrodar.

According to the time of the beginning of the use of drugs in medicine, there are:

• First generation drugs - Alflutop and Rumalon.
• The second generation drugs include drugs based on hyaluronic acid, glucosamine and chondroitin sulfate.
• Third generation drugs include hydrochloride in combination with chondroitin sulfate.

In addition, chondroprotectors differ in the way they are used:

• Preparations for internal use. These include Structum, Artra, Teraflex, Formula C, Piascledin. The therapeutic effect of their intake is manifested 3 months after the start of treatment, and after six months a stable relief of the disease is established. These drugs differ in that they are almost always well tolerated by patients and do not cause side effects.
• Injectable drugs. This group includes Adgelon, Alflutop, Chondrolon, Noltrex, etc. The effect of treatment is achieved much faster than when taking drugs orally, but it is shorter and the course of treatment must be repeated every 6 months.
• Substitutes for intra-articular fluid. These are products based on hyaluronic acid. These include Ostenil, Synocrom, Fermatron and Synvisk. They are injected directly into large joints and replace the intra-articular fluid, the production of which is often reduced in joint diseases. The course of treatment includes 3-5 injections, but sometimes one injection is enough. You can repeat the course only after 6 months.

Chondroprotectors for joints are prescribed only by a doctor after a thorough examination.

It depends on the exact diagnosis, which drug will be used.

The main diseases for the treatment of which chondroprotectors are used

Coxarthrosis

This is a disease in which physiological wear of the joint occurs and its functional activity is limited.

For its treatment, chondroprotectors are prescribed, which include chondroitin sulfate and glucosamine.

The drug of choice is Teraflex.

It not only stimulates cartilage regeneration and the production of a healthy matrix, but also provides protection against cartilage damage.

When treated with this chondroprotector, the need for non-steroidal anti-inflammatory drugs is significantly reduced.

In addition to Teraflex, Chondroxide is often prescribed in the treatment of coxarthrosis.

It stimulates the regeneration of the articular bag and improves the metabolism in fibrous and hyaline cartilage.

Osteochondrosis

A disease in which intervertebral discs are affected together with the ligamentous apparatus of the spine and adjacent vertebral bodies.

For the treatment of this disease, drugs are used that help restore the cartilage tissue of the intervertebral joints and reduce pain.

These are mainly Dona, Artra and Structum.

In the treatment of osteochondrosis, it is especially important to start treatment as early as possible; in advanced cases of the disease, chondroprotectors are practically useless.

In addition, they must be used simultaneously with other medicines- non-steroidal anti-inflammatory drugs (Diclofenac, Voltaren) and vitamin complexes(Milgamma).

The scheme of taking drugs and their combination should be selected by the doctor after a thorough examination.

Arthrosis

This is a dystrophic change in the articular surfaces of a chronic nature.

There are many both positive and negative reviews about the effectiveness of the use of chondroprotectors in this disease.

It should be noted that positive dynamics is observed only at the beginning of treatment for early stages disease and subject to taking drugs for a long course.

The drugs of choice in this case are mainly Artron flex, Dona, Teraflex and Alflutop.

They improve the lubricating properties of the intra-articular fluid and stimulate its production.

Diseases of the spine

Chondroprotectors are prescribed for vertebral arthritis, spondylosis, osteochondrosis, spinal injuries and in the postoperative period.

The most commonly used Alflutop, Rumalon, Artrodar (complex drug) and other drugs prescribed by a doctor.

Since the disease of the spine destroys the cartilage tissue and reduces the interarticular fluid, the main task of chondroprotectors for the joints is to normalize the physiological composition of the cartilage tissue, thereby contributing to its restoration.

This reduces the swelling of the joints, their stiffness and the intensity of pain.

Another action of chondroprotectors is the normalization of the composition and amount of synovial fluid. This helps restore joint function and strengthen cartilage.

Chondroprotectors also have an anti-inflammatory effect.

But this effect appears after 2 - 3 weeks after the start of treatment and it lasts for quite a long time.

This is what distinguishes chondroprotectors for joints from other anti-inflammatory drugs.

Arthritis

Inflammatory disease leading to malnutrition of the joint.

In its treatment, chondroprotectors are used together with painkillers and anti-inflammatory drugs.

Prescribed mainly drugs containing chondroitin sulfate and glucosamine. These are Structum, Dona, Artron flex and Chondroxide.

This treatment reduces pain syndrome and swelling, the mobility of the joint returns.

In case of damage to large joints (knee), chondroprotectors are introduced into the joint.

List of the most effective drugs for joints

Teraflex

A complex preparation that includes chondroitin sulfate and glucosamine.

It is used for osteochondrosis of the spine, arthrosis, joint injuries.

Contraindicated in people suffering from phenylketonuria.

In rare cases, it may cause an allergic reaction. It is taken orally, the regimen and dosage are prescribed by the doctor.

Don

The main active ingredient is glucosamine sulfate.

It affects the metabolic processes in cartilage tissues and has an anti-inflammatory effect. It is prescribed for arthrosis, osteochondrosis and arthritis.

It is taken orally, in the form of a powder, which must be dissolved in water, or injected intramuscularly.

The method of administration and dosage is prescribed by the doctor after the examination.

Artra

By popularity, this drug is in first place.

It has a complex composition, which includes glucosamine hydrochloride and chondroitin sulfate.

It is mainly used for arthrosis and osteochondrosis.

Contraindicated in people with impaired renal function and children under 15 years of age.

Patients with diabetes and bronchial asthma should be treated under medical supervision. The dosage and treatment regimen is also prescribed by the attending physician.

Structum

The main composition is chondroitin sulfate.

It is used for arthrosis and osteochondrosis, contraindicated in thrombophlebitis.

Available in capsules, dosage and regimen are prescribed by a doctor.

Formula - C

A prophylactic drug that includes glucosamine sulfate and chondroitin sulfate.

It is used not only for arthrosis, arthritis, joint injuries and osteochondrosis, but also for bedsores and burns, as it accelerates the healing process.

Taken as a capsule 2 times a day, preferably after meals.

The course of admission is at least two months.

Alflutop

Natural chondroprotector, includes an extract of four types of Black Sea fish.

Improves metabolism in cartilage, has anti-inflammatory properties. Indicated for use in osteochondrosis, spondylosis, arthrosis, periarthritis (inflammation of the periarticular tissue), in the postoperative period.

Possible individual intolerance to the drug.

Side effects can sometimes occur - pain in the joints and muscles around the site of intramuscular injection of the drug.

The course of treatment is 20 days.

If large joints are affected, Alflutop is injected into the joint. The interval between such injections should be at least 3-4 days.

In severe cases, simultaneous intraarticular and intramuscular administration of the drug is possible.

"Toad Stone"

This is an herbal medicine.

It is not a chondroprotector and is considered a biologically active food supplement.

It contains the grass of the field toad, which contains glucosamine sulfate and chondroitin sulfate.

Available in the form of capsules taken orally and as an ointment for external use.

Take 1 capsule 3 times a day for a month.

Taking chondroprotectors is extremely rarely accompanied by side effects: sometimes patients complain of nausea, diarrhea, and abdominal pain.

Contraindications for prescribing drugs are pregnancy, lactation and allergies to the substances that make up their composition.

Chondroprotectors should be taken with caution by people suffering from diabetes.

People taking chondroprotectors should remember that in order to increase the effectiveness of the drugs:

• It is necessary to perform physical therapy exercises daily ( physiotherapy exercises). They are performed sitting or lying down, they provide a load not on the joint, but on the muscles surrounding it.
• Physical activity must necessarily be combined with periods of rest. Every hour of activity should be followed by 5 to 10 minutes of rest.
• Do not allow hypothermia of the lower extremities.
• It is very useful to walk on a flat surface for about half an hour a day.
• If you are overweight, it is imperative to take measures to lose weight - visit a nutritionist and choose the appropriate diet. Very often, with a decrease in body weight, joint pain is significantly reduced.
• If possible, sudden movements should be avoided, which can lead to additional stress on the diseased joint.

Prices

These are quite expensive drugs.

The cost of a monthly course of treatment can range from 2000 to 5000 rubles.

In some cases, you can replace the drugs with their components, produced separately.

So, for example, the price of Don's drug is about 1000 rubles. It includes glucosamine, the cost of which, as a separate agent, does not exceed 300 rubles. Chondroitin costs the same.

But it is far from always possible to replace drugs in this way, so a thorough examination and consultation of a specialist is so necessary.

Dear friends, hello!

After a short break, we return to the conversation about drugs, and today's conversation will be devoted to a group that causes a lot of controversy. We will talk about chondroprotectors.

Throughout the past week, I have been studying this issue and came to the conclusion that modern chondroprotective drugs are still a “dark horse”.

But one thing is clear: the whole people is divided in relation to this group into 2 camps. And they all share:

1. Doctors. Some consider chondroprotectors to be the main pathogenetic treatment for arthrosis. Others say it's clean water profanation. The latter, in particular, include your beloved Elena Malysheva, who from the big podium, or rather, directly from the TV, said that chondroprotectors are drugs with unproven effectiveness.
2. Pharmacy staff. Some, having read publications and clinical studies, think the same way as a TV star. Others argue that chondroprotectors really work. This, firstly, is said by grateful customers, secondly, “I took it myself, it became easier”, thirdly, “I gave it to my mother, there is an effect.”
3. Sufferers who know what it is, firsthand. Some write reviews like: “drank, it’s no use. Just wasted money." Others retort them: “But it helped me!”

After studying and comprehending the videos, clinical studies and the opinions of doctors, I formed my own opinion.

CHONDROPROTECTOR DRUGS WORK, unless…

Although no, we will not run ahead of the locomotive.

I feel now how happy the supporters of this group were, and how their opponents frowned, dreaming of throwing rotten tomatoes at me.

Do not order to execute, order to say a word!

Moreover, it is in your own interests to fall in love with this group of funds: otherwise, how are you going to sell them?

We will now consider the following questions:

• Why don't chondroprotectors always help?
• How do they share?
• Why do they have side effects?
• Which is better: a single drug or a combination drug?
• What are the features and "chips" of popular chondroprotectors?

But first, as usual, let's remember how the joint is arranged in our body, and due to what it works.

How is the joint arranged?

So, the joint is a connection of articular surfaces of bones, each of which is covered with cartilage.

The joint is enclosed in a joint bag, or capsule, which is attached to the articulating bones. It provides tightness of the joint and protects it from damage.

The cartilage of the joint is a kind of gasket that is necessary for the smooth sliding of the heads of the bones relative to each other and for absorbing the loads that the joint experiences during movement.

Between the heads of the bones is a slit-like space - the joint cavity.

The inner lining of the joint capsule is called synovial and produces synovial fluid into the joint cavity.

Synovial fluid is needed to lubricate the articular surfaces of the bones, so that the cartilage does not dry out, and for all the functions of the ship to work properly.

Cartilage resembles a sponge in its structure: when loaded into the joint cavity, synovial fluid is released from the cartilage, and as soon as the compression stops, the fluid returns back to the cartilage.

What is articular cartilage made of?

Cartilage is made up of collagen fibers that run in different directions to form a network. The mesh cells contain proteoglycan molecules that hold water in the joint. Therefore, cartilage is approximately 70-80% water.

Proteoglycans are made up of protein and glycosaminoglycans.

Glycosaminoglycans are carbohydrates, which include hyaluronic acid and chondroitin sulfate, among others. Look at the picture above: chondroitin is the brush hairs in proteoglycans.

Both require glucosamine to produce. It is formed by cartilage tissue cells, chondrocytes, from substances that enter the body with food.

In other words, glucosamine is the building block for chondroitin. And chondroitin is needed for the synthesis of hyaluronic acid.

What is synovial fluid?

It is a blood plasma filtrate, which contains hyaluronic acid, obsolete joint cells, electrolytes, proteolytic enzymes that destroy old proteins.

Hyaluronic acid binds and retains water in the joint cavity, due to which the synovial fluid moisturizes the articular surfaces of the bones, and they move relative to each other like clockwork.

And one more important point. The fluid in the joint cavity is not worth it, as in a swamp.

She circulates. Old cells die, new ones are born, the blood plasma filtrate is renewed, and for this process, like air, movement is necessary.

How is the joint fed?

The nutrition of the joint leaves much to be desired.

It has no independent blood supply.

Its “nurse” is the synovial fluid, from where the cartilage, through osmosis, that is, leakage, takes the nutrients it needs. And they enter the synovial fluid from the blood vessels passing near the joint.

But even here it is not so simple.

The cartilage absorbs the synovial fluid only during movement: the leg was bent, the synovial fluid came out of the cartilage into the joint cavity, straightened it went back into the cartilage, delivering the necessary “food” to it.

When moving, the muscles that attach to the elements of the joint contract, and due to this, blood is pumped through their vessels, delivering more nutrients to the cartilage.

More about chondrocytes

Chondrocytes are involved in the restoration and production of substances necessary for cartilage. But the whole problem lies in the fact that there are very few of them: only 5%, and everything else (95%) is cartilage matrix (collagen fibers).

In addition, among chondrocytes there are young, mature and aged cells. The parade is commanded, of course, by mature people. Others either STILL do not have enough strength to synthesize the substances necessary for cartilage, or ALREADY do not have enough.

But with adequate loads and normal nutrition of the joint, this is enough.

conclusions

Thus, for the normal operation of the joint, you need:

1. Mature chondrocytes receiving adequate nutrition.
2. Normal blood supply to the joint.
3. Adequate work of the muscles surrounding the joint.

Why does arthritis develop?

It most often develops as a result of one of four problems:

1. Or they overloaded the joint (excess weight or sports loads that exceed the ability of the cartilage to extinguish them).
2. Or they didn’t load it (physical inactivity, as a result of which the blood supply to the joint is disturbed, the cartilage does not receive adequate nutrition and begins to collapse).
3. Or all together (+ hypodynamia).
4. Or a serious injury in which the metabolism in the joint and its nutrition are disturbed.

What happens in the joint under the influence of these factors?

1. Chondrocytes do not have time (with OVERLOAD) or cannot (with UNDERload) form a sufficient amount of glucosamine.
2. If there is no glucosamine, chondroitin is not formed.
3. If chondroitin is not formed, hyaluronic acid is not formed.
4. If hyaluronic acid is not formed, fluid is not retained in the joint.
5. If there is little fluid in the joint, the articular heads of the bones are not moistened.

And then this is what happens:

Stages of arthrosis

Stage 1 arthrosis:

1. Cartilage loses water, i.e. dries up.
2. Collagen fibers are torn or completely destroyed.
3. The cartilage becomes dry, rough and cracks.
4. Instead of sliding freely, the cartilages of the articulating bones "cling" to each other.

Stage 2 arthrosis:

1. The pressure on the bone increases.
2. The heads of the bones begin to gradually flatten out.
3. The cartilage thins out.
4. The joint space is reduced.
5. The joint capsule and synovial membrane "wrinkle".
6. Bone outgrowths - osteophytes - appear along the edges of the bones.

Stage 3 arthrosis:

1. The cartilage disappears completely in places.
2. The bones begin to rub against each other.
3. The deformity of the joint increases.

Stage 4 arthrosis:

1. The cartilage is completely destroyed.
2. The joint gap is practically absent.
3. The articular surfaces are exposed.
4. The deformity of the joint reaches its maximum.
5. Movement is not possible.

As a result of these changes, inflammation develops in the joint. It becomes edematous, but intensifies.

Now let's move on to the drugs.

But first, a few basics.

When do chondroprotectors "work"?

First of all, let's clarify the following for ourselves:

1. Chondroitin and glucosamine are effective on 1-2 stages of arthrosis, when there is no cartilage destruction yet, and chondrocytes are alive.
2. Chondroitin sulfate is a large molecule, about 100 times larger than glucosamine, so its bioavailability is only 13%.
3. The bioavailability of glucosamine is greater, but also not much, only 25%. This means that 25% of the dose taken will reach the joint directly.
4. The optimal therapeutic dosages of chondroprotectors for oral administration, according to practitioners, are as follows:

1. To get real results, you need 2-3 courses of treatment with these drugs, which will take up to 1.5 years.
2. Practitioners advise taking chondroprotectors continuously for 3-5 months and repeating the course every six months.
3. Chondroprotectors should be taken regularly, in courses, and not on a case by case basis.
4. It is pointless to take chondroprotective drugs if you continue to mock the joint with excessive loads. To achieve the effect, you need to reduce weight, and athletes abandon conventional training.
5. You can take this group for a very long time and not see the result if you do not provide normal nutrition to the joint. This requires special (!) Exercises.
6. For the production of chondroitin and glucosamine, cartilage of cattle, extracts from marine fish are used. It is difficult to achieve 100% purification, therefore, when taking these drugs allergic reactions occur and problems from the gastrointestinal tract (abdominal pain, diarrhea, constipation, etc.).
7. Chondroitin sulfate reduces clotting blood, so it can not be used together with anticoagulants and with a tendency to bleeding.
contraindicated pregnant and lactating women, children.
8. Diabetics when taking these drugs need to carefully control their sugar levels. It can rise (carbohydrates after all).

How do chondroprotectors work?

What does glucosamine do?

• Stimulates the activity of chondrocytes.
• Necessary for the synthesis of chondroitin sulfate and hyaluronic acid.
• Prevents the destructive effect on the cartilage of NSAIDs and glucocorticosteroids.

What does chondroitin sulfate do?

• Necessary for the synthesis of hyaluronic acid.
• Normalizes the production of synovial fluid.
• Reduces the activity of enzymes that damage cartilage.
• It has an anti-inflammatory effect.

Types of chondroprotectors

Let's analyze how chondroprotectors are divided.

According to the way of taking exists:

• Preparations for oral administration (Struktum, Dona powders and tablets, Artra, etc.)
• Preparations for injections (Dona r / r, Alflutop, Rumalon, etc.)
• Preparations for external use (Chondroxide, Chondroitin, etc.).

With parenteral administration, the bioavailability of chondroprotectors is significantly higher, so they are prescribed when you need to quickly relieve an exacerbation, or when the patient prefers short courses of treatment, or when there are problems with the liver, so as not to burden it.

Preparations for external use are effective only in combination with other forms of release.

By composition, chondroprotectors are divided into:

• Monopreparations that contain only chondroitin sulfate (CS) or glucosamine (GA): Structum, Don.
• Combined products containing both one and the other component: Artra, Teraflex.
• Means that, in addition to cholesterol and GA, contain a non-steroidal (i.e., non-hormonal) anti-inflammatory agent: Teraflex Advance.

With the latter, everything is clear: if there are signs of inflammation (severe pain, swelling), at first we recommend a drug with NSAIDs. After 2-3 weeks, you can switch to a "clean" chondroprotector.

As for the first two, there is no unequivocal answer to the question “which is better”. Some doctors prefer single drugs, others combined, and still others prescribe both, depending on the situation.

But I noticed that glucosamine gives more side effects from the gastrointestinal tract.

Therefore, the combination of GA and CS seems to me the most optimal: it increases the bioavailability of the drug and reduces the frequency of adverse reactions.

Well, now let's go over the drugs.

I'll start with the "oldies":

RUMALON- solution for intramuscular injection.

Compound:

Glycosaminoglycan-peptide complex derived from cartilage and bone marrow of calves (powerful allergen due to animal proteins).

What is he doing:

It improves the synthesis of cholesterol, promotes the maturation of chondrocytes, stimulates the synthesis of collagen and proteoglycans. Moreover, the manufacturer writes that the drug is effective both in the early and late stages of arthrosis. The latter makes me doubt.

Application: administered according to the scheme for 5-6 weeks, 2 times a year.

Side effects: allergic reactions.

ALFLUTOP- injection.

Ingredients: bioactive concentrate from small marine fish.

Contains amino acids useful for cartilage, mucopolysaccharides, trace elements: sodium, magnesium, zinc, iron, etc.

What it does: It inhibits the activity of hyaluronidase, an enzyme that breaks down hyaluronic acid. So the latter becomes larger, and the condition of the cartilage improves.

Application:

There are 2 ways to use it:

1. Intramuscularly daily 1 ml for 20 days.
2. Intra-articular 1 or 2 ml per joint every 3-4 days. Only 5-6 injections.

The course is repeated after six months.

Sometimes doctors start with intra-articular injections, then move on to intramuscular injections. It depends on the doctor. How many doctors, so many methods.

Contraindications: Allergy to seafood (sometimes very strong).

CHONDROLONE- lyophilisate (i.e. the active substance is in a dried state) for the preparation of a solution

Composition: contains chondroitin sulfate 100 mg per ampoule.

Since the bioavailability is high with this administration, this dosage is sufficient.

It is obtained from the cartilage of the trachea of ​​cattle.

What it does: inhibits the activity of enzymes that cause cartilage destruction, stimulates the production of glycosaminoglycans by chondrocytes, normalizes the production of synovial fluid, and has an anti-inflammatory effect.

Application: in / m 1-2 ampoules every other day. Only 25-30 injections. The course is repeated after six months.

DONA- monopreparation.

Ingredients: contains glucosamine sulfate.

What it does: stimulates the synthesis of hyaluronic acid and other glycosaminoglycans, inhibits enzymes that cause cartilage destruction.

In one tablet 750 mg HA.

How to take: 1 t. 2 times a day with meals. Improvement occurs in 2-3 weeks. The minimum course is 4-6 weeks. Repeat the course after 2 months.

The powder contains 1500 mg of HA.

For whom is it optimal this form of release: powders are especially good for working citizens, who find it more convenient to take the drug only 1 time per day.

And also for those who have difficulty swallowing tablets.

Application: the powder is dissolved in a glass of water and taken 1 time per day (also better with meals). The course is 6 weeks, repeated after 2 months.

Solution for i / m administration: in 1 ampoule 400 mg of glucosamine. Bioavailability 95%. In addition to glucosamine, it contains lidocaine, therefore it has many contraindications: cardiovascular insufficiency, impaired liver and kidney function, epileptic seizures, etc. There are many side effects.

Medical prescription only!

Application: Enter 3 times a week for 4-6 weeks. And then as the doctor decides. Maybe he will switch to powders or tablets.

STRUKTUM- capsules.

Ingredients: contains chondroitin sulfate.

There are 250 mg and 500 mg. To be honest, I don’t know why the first form of release exists, since the manufacturer recommends taking 500 mg 2 times a day.

Judging by the presence in Moscow pharmacies, Structum 250 mg is leaving the shelves. Maybe I'm wrong.

What is he doing? Stimulates the synthesis of glycosaminoglycans, improves metabolic process in cartilage.

Application: take it 500 mg 2 times a day for 6 months.

The action after cancellation lasts 3-5 months, then you need to repeat the course.

- combined remedy.

Composition : contains very adequate dosages of chondroitin and glucosamine: 500 mg each

What it does: All the good things HA and CS do in the joint.

Application: take this drug 1 ton 2 times a day for the first 3 weeks, then 1 ton a day for a long time, but not less than 6 months.

TERAFLEX ADVANCE - another combination drug.

Composition: it contains: GA 250 mg, cholesterol 200 mg and ibuprofen 100 mg.

So, in addition to all the beneficial effects of the first two substances, it also has an anti-inflammatory and analgesic effect.

In addition to all the beneficial effects of the first two substances, it also has an anti-inflammatory and analgesic effect.

True, contraindications and side effects due to ibuprofen become several times larger.

Application: take it 2 capsules 3 times a day after meals for no more than 3 weeks. Then they switch to the usual Teraflex.

TERAFLEX

Composition: contains GA 500 mg, cholesterol 400 mg.

Application: take it for the first 3 weeks, 1 capsule 3 times a day, then 1 capsule 2 times a day for 3-6 months, preferably with meals. Then, as usual, the course is repeated.

External chondroprotectors

Here I will focus only on the most popular drug Chondroxide.

CHONDROXIDE

Composition: contains 1 g of 50 mg of chondroitin sulfate.

Release form: ointment and gel.

Application:

A large molecule of chondroitin cannot penetrate the skin on its own, therefore, in order to pass it through cell membranes, dimexide is added to the drug, which also has an anti-inflammatory and analgesic effect.

Do not apply to open wounds.

CHONDROXIDE FORTE – cream

Composition: contains cholesterol and the anti-inflammatory substance Meloxicam, that is, it reduces inflammation and pain.

Contraindications standard for NSAIDs.

Given this composition, it is better not to advise the elderly. For them, there is a gel for the period of exacerbation.

This is not just a cream, it is a transdermal glucosamine complex (glucosamine + triglycerides).

Compound . contains glucosamine, and not chondroitin, like the previous forms, and dimexide, so we recommend it when it was noted in the past allergic reaction on other external forms of chondroxide.

And also when the buyer does not care about the high price. The main thing is that the effect is maximum.

The active substance is enclosed in a shell of lipids, which together form a micelle (nanoparticle), which delivers the active substance to the joint in a concentration comparable to an injection.

Application: apply it 2-3 times a day for 3-4 weeks. If necessary, the course is repeated.

I end with this.

You have a lot of chondroprotectors in your assortment: both drugs and dietary supplements.

But knowing the basic things that I talked about, you can now independently understand the composition of such a tool and its effectiveness.

I hope that now you can easily continue the phrase:

CHONDROPROTECTORS WORK, unless…

And as homework I suggest you think:

What questions should a buyer ask when choosing a chondroprotector?

Having studied everything thoroughly, I understood why in some countries all chondroprotectors are considered additives: because their bioavailability is low (and manufacturers, by the way, do not hide this), and the therapeutic effect is greatly delayed in time.

And in conclusion, I will answer the most common question:

Why are there many bad results of using chondroprotectors?

1. Because, as usual, people are hoping for a magic pill without putting in the effort to lose weight and work muscles.
2. Because they want quick results, and not seeing them, they stop treatment.
3. Because they begin to "drink Borjomi when the kidneys have failed", i.e. take chondroprotectors at 3-4 stages of arthrosis.

That's all.

How did you like this article, friends?

What do you think about chondroprotectors YOU?

Add, comment, share your experience, click on the social buttons. networks.

See you on the blog for hard workers!

With love to you, Marina Kuznetsova

Diseases of the musculoskeletal system are most common in the elderly, but every year the disease "gets younger" and can bother even at the age of 20-30 years.

Degenerative pathology of bones and joints is characterized by the gradual destruction of cartilage tissue. This leads to limited mobility and severe pain.

Such diseases belong to the group of socially significant ones, they are the primary source of temporary or permanent disability, do not allow you to enjoy life to the fullest and do what you love.

The sooner you start treating the pathology of the musculoskeletal system, the faster you can feel the effect. Among the innovative means are chondroprotectors- These are special broad-spectrum drugs used to treat bones and joints.

The group includes both medicinal substances and biologically active additives. In the later stages of the development of the disease, chondroprotectors do not have sufficient effectiveness, their use does not bring practical benefits.

The very name of the drug (in the translation "chondro" - cartilage and "protection" - protection) indicates that the chondroprotector provides optimal protection of the articular cartilage from destruction. Manufacturers focus on the fact that taking drugs helps to restore damaged cartilage, reduce the manifestations of articular pathology. At the same time, there is a noticeable decrease in pain, which gradually disappears completely.

Chondroprotective drugs of the new generation are the most effective today, besides them, a medicine has not yet been invented that can restore cartilage tissue and protect joints.

Mechanism of action

You can understand the effect of chondroprotectors if you carefully consider the anatomical structure of the joints. The surface of the bones of the articulation is covered with a moistened smooth layer.

Throughout life, cartilage cells produce a special fluid - synovial. It nourishes the cartilage tissue, prevents it from drying out. Fluid production is possible only if the joint is regularly in motion, the more active it is, the more fluid is produced.

The destruction of cartilage, regardless of the cause of the pathology, is accompanied by exposure of bone tissue. Its surface loses its natural smoothness, becomes rough and inhomogeneous. Even if the opposite cartilage has retained its integrity, it is destroyed upon contact with such a surface.

A natural process is a violation of the production of synovial fluid. At the same time, the joints lose lubrication, cartilage does not receive the necessary nutrition to maintain structure and regenerate.

The articulation loses its functions, there is a slow but inevitable necrosis of the cartilaginous tissue. Chondroitin with glucosamine for joints, applied in a timely manner, prevent further destruction of cartilage.

In parallel, they remove the inflammatory process and reduce pain. These drugs contain components produced by the human body. They restore the ability of cartilage tissue cells to produce synovial fluid in the same volumes.

Chondroprotective drugs usually consist of two active ingredients ( chondroitin and glucosamine), in some recipes only one is found. Each of the components affects the cells of cartilage and bone tissue in different ways, depending on the mechanism of their action.

Chondroitin has the following effect:

• preserves the integrity of the cartilage, prevents its destruction;
• stimulates the production of collagen, hyaluronic acid and other components of cartilage tissue;
• effectively relieves inflammation;
• activates the production of lubrication.

The mechanism of action of glucosamine is slightly different:

• effectively relieves swelling around the articular joints;
• relieves inflammation;
• protects cartilage from the effects of free radicals, has an antioxidant effect;
• promotes the synthesis of substances involved in the regeneration of cartilage.

Such a combination as chondroitin with glucosamine for joints , improve the condition of the soft tissues located around the bone joint. In addition to these two active substances, chondroprotectors may also contain other components, natural or synthetic, that enhance the effect of the drug.

Classification of chondroprotectors

This group of drugs is classified according to several criteria. The first is the components included in medicine. According to this classification, there are:

• Preparations based on chondroitin sulfate. This component is sometimes called building material for elements of the musculoskeletal system, in particular joints. Chondroitin sulfate prevents the destruction of cartilage, relieves pain, stimulates the production of synovial fluid.
• Medicines made from animal bone marrow and cartilage(cattle or calves). They prevent degenerative changes in cartilage tissue, promote its regeneration.
• Mucopolysaccharides. The main active ingredient is glucosamine, for the joints it is indispensable, as it restores cartilage tissue and significantly slows down degenerative processes.
• Complex preparations. They contain glucosamine, chondroitin and other excipients. They fight inflammation, restore joint mobility. Sometimes they are called chondroprotectors for new generation joints.

There is another classification according to which drugs are distinguished by generations:

• first generation. The simplest ingredients.
• second generation. In addition to the main components, they contain hyaluronic acid, glucosamine, chondroitin.
• third generation. Have complex composition, it includes chondroitin with glucosamine for joints.

Also, drugs are classified according to the method of administration:

• Oral administration. These are tablets or capsules, the shell of which dissolves in the stomach. It differs in the duration of exposure, the effect can be expected no earlier than after 3 months. Relief, felt by the patient, occurs only after six months. They have proven themselves among patients of all ages, are well tolerated and do not show side effects that are not always mentioned in advertising.
• Injections. Thanks to this form of release, they allow you to quickly achieve the effect, since the active substances are instantly carried through the bloodstream and act in the right place. Their disadvantage is that the expected result is not so long, the course of treatment is repeated approximately every six months.
• Creams and ointments, which include glucosamine with chondroitin. Applied to the affected areas externally, provide temporary relief.
• Substitutes for intra-articular fluid. These medicines include various active substances, the main one being hyaluronic acid. They are injected into large joints with a thin needle. The procedure is quite painful, patients are tolerated in different ways. Only 3-5 injections are needed for the patient to receive lasting relief for a sufficiently long period of time. Such a chondroprotector replaces the intra-articular (synovial) fluid, the production of which is significantly reduced under the influence of pathologies.

What scientists say about different generations of chondroprotectors

It is important to listen to the opinion of scientists who study chondroprotectors and have managed to collect a lot of facts about their effectiveness. They believe that the first generation practically does not give a significant result, regeneration of cartilage tissue under the influence of such chondroprotectors is unlikely.

The reason is the simplest active substances that can only slightly affect the affected cartilage and the degree of synovial fluid production. These chondroprotectors are a kind of placebo, an imitator of strong drugs, which does not contain an active active ingredient.

Chondroprotectors 2nd and 3rd generation deserve more attention, they also contain glucosamine, chondroitin and other substances. They demonstrate a clinically proven result, in accordance with studies of the main and control groups of patients.

They are widely used in international practice, they are very popular not only in Russia, but also in the best clinics in America, Israel, Canada.

The cost of drugs, which include chondroitin sulfate, is high, you need to repeat the course of treatment several times. However, the lasting effect and the complete disappearance of painful sensations are fully consistent with such costs.

Chondroitin with Glucosamine for joints – the most effective remedy to date, however, this characteristic is largely determined by the intake of active substances into the patient's body.

Local forms of chondroprotectors, ointments or creams, are rubbed into the skin, improve blood flow, but relieve symptoms only partially and for a short time.

The reason is that they are not fully absorbed into the blood. Scientists recommend using natural products containing glucosamine, chondroitin sulfate and hyaluronic acid.

If you regularly use fish or meat broth, jelly, jelly, stew of cattle with cartilage and joints, decoction of chicken heads, avocado or soy, you can significantly improve the condition of cartilage tissue.

Chondroprotectors for joints of a new generation in the form of tablets widely advertised by various manufacturers of such drugs.

However, they cause the most intense controversy among scientists. Indeed, in the stomach and intestines, drugs are quickly absorbed, enter directly into the cartilage tissue and actively nourish it.

However, there are negative opinions about this form of the drug. If the gastric mucosa in the body is affected, it will only aggravate the patient's condition.

The most effective form is injections, the active substance is quickly absorbed into the bloodstream and enters the affected area.

Another one that is introduced into the articular cavity, according to scientists, is quite effective. These are chondroprotectors of a new generation, the synovial surface is replaced instantly, the pain immediately disappears, the cartilage is saturated with useful substances, the joints optimally glide relative to each other, and the crunch disappears.

A huge disadvantage of this treatment method is the high cost of chondroprotectors.

List of drugs (list of drugs with a description of actions and current prices)

The list of the following drugs is most popular among those whose joints are worn out or the cartilage does not produce synovial fluid in the right amount.

• RUMALON- Available in the form of a solution for intramuscular injection.

Active ingredients: Glycosamioglycan is a peptide complex that is obtained from the bone marrow and cartilage of young calves.

Action: promotes the regeneration of cartilaginous tissue, stimulates the synthesis of collagen fibers. It is effective for arthritis both in the early and late stages (according to the manufacturer). Warning: a powerful allergen due to the animal proteins that make up the composition.

Price: from 1350 rubles.

• ALFLUTOP- injection.

Active ingredients: extract from small marine fish.

Action: improves the condition of cartilage by inhibiting the activity of hyaluronidase. As a contraindication is an allergy to seafood.

Price: from 1580 rubles.

• CHONDROLONE- lyophilisate for preparation of intramuscular injections.

Action: stimulates the production of glycosaminoglycans by cartilage cells, relieves inflammation, normalizes the production of synovial fluid.

Price: from 720 rubles.

• DON.

Active ingredients: glucosamine sulfate.

Action: stimulates the production of hyaluronic acid, prevents the destruction of cartilage. The drug glucosamine has many contraindications, it should not be taken by people with heart, kidney and liver failure.

Price: from 1250 rubles.

• STRUKTUM- Available in capsules.

Active ingredients: chondroitin sulfate.

Action: stimulates the synthesis of glycosaminoglycans, gradually regenerates cartilage.

Price: from 1400 r.

• CHONDROMED

Active ingredients: chondroitin sulfate.

Action: eliminates inflammation in the joints, protects the connective tissue, effectively restores the articular bag. Chondromed promotes the formation of lubrication of articular surfaces, which relieves crunch and pain.

PRICE: from 400 rubles.

What diseases are chondroprotectors indicated for?

Preparations based on chondroitin sulfate are used for various degenerative diseases of cartilage, bones, joints.

They appear in the appointment of a doctor for the following pathologies:

• arthrosis of large joints;
• pseudoarthrosis;
• meniscopathy;
• arthritis;
• periarthritis.

Each of the diseases has its own group of drugs.

Chondroprotectors for joints, the list of which is presented above, are widely used in modern medical practice and are available in almost all pharmacies.

Their only "disadvantage" from the point of view of the consumer is the high price (considering the duration of the course).

How to choose chondroprotectors

The choice of drugs in this category is wide, it is not always possible to choose a good and effective chondroprotector the first time.

Usual medical practice: the initial prescription of the drug in the form of intramuscular or intraarticular injections, then the transition to oral administration in the form of capsules or tablets is carried out.

Also, to consolidate the effect, you can use gels and ointments (glucosamine with chondroitin). They are quickly absorbed, do not leave a sticky residue on the skin, so they can be used before going to work or school.

It is also necessary to pay attention to side effects carefully study the instructions for use of the drug.

The country of origin also plays a huge role, medicines from pharmacological brands of America, Russia, Western Europe and Canada.

How to take chondroprotectors

Doctors emphasize that only cartilage that has not yet been completely destroyed can be restored. The use of chondroprotectors is justified in the early stages of any disease caused by pathologies of the musculoskeletal system.

Preparations based on chondroitin and glucosamine are taken for a long time, sometimes time is extended by 1-2 years.

You should not limit yourself to one course, since full-fledged regeneration of cartilage tissue is possible only with regular medication at regular intervals.

It is not necessary to expect quick results, any processes, including regenerative ones, in the cartilage tissue proceed slowly, premature interruption of the course of treatment is fraught with further destruction of the cartilage.

A persistent long-term effect occurs, if you take the chondroprotector prescribed by the doctor from 6 months to 1.5 years. In no case should you choose drugs, focusing on advertising on TV or in a pharmacy.

The duration of the course, the name of the medicine, the daily allowable dose, as well as the possibility of its further increase to increase efficiency, are prescribed by the doctor.

As practice shows, preparations based on chondroitin sulfate are easily tolerated by patients at any age, side effects do not occur.

In rare cases, there are intestinal disorders that are easily corrected with appropriate drugs to normalize the microflora of the stomach.

Contraindications

Chondroprotectors have contraindications. With caution, such drugs are prescribed to patients with:

• allergic intolerance to any active ingredient;
• in early childhood;
• during pregnancy and lactation;
• with an established diagnosis.

Chondroprotectors, although inexpensive, do not contribute to the development of new cartilage tissue in the joints, but they regenerate old cartilage, normalize the structure of this tissue, relieve inflammation and pain. In addition, such drugs contribute to the active formation of synovial fluid.

List of drugs

Today we will talk about Russian-made chondroprotectors for people suffering from joint ailments:

It is produced in several states, but there is also Russian-made Rumalon (from Neopharm). Price - up to 1409 rubles. The remedy is made from the bone marrow and cartilage tissues of calves. It is used intramuscularly, inhibits destructive processes in cartilage, spurs regeneration processes. Effective:

1. at ;
2. coxarthrosis;
3. spondylarthrosis;
4. spondylosis;
5. gonarthrosis;
6. meniscopathy;
7. chondromalacia of the patella.

Contraindicated in case of hypersensitivity, may provoke allergic reactions.

Production - Russia (LLC "Inkapharm"). Price - 679 rubles. The active substance is chondroitin sulfate. Available in ampoules. Injected intramuscularly every other day. The course is about 30 injections.

Among the contraindications are not only hypersensitivity, but also early age, bleeding and a tendency to them, thrombophlebitis, breastfeeding, pregnancy.

Side effects - hemorrhages at the injection site, allergies. There is also an ointment artradol, which enhances the effect of the drug.

Available as an ointment and tablets. Price from 353 rubles. Better to use at the same time. The active substance is chondroitin sulfate. Contraindicated in case of hypersensitivity, as well as for pregnant and lactating women. Use with caution if you are prone to bleeding. Side effects:

1. disorders of the stomach and intestines;
2. allergies (rare).

If the drug is used together with antiplatelet agents, anticoagulants, fibrinolytics, blood clotting must be constantly monitored.

Another drug of Russian production. Price 387 rubles, the active ingredient is chondroitin sulfate. Produced from the trachea of ​​cattle. Mukosat is administered every other day intramuscularly every other day.

Contraindicated in thrombophlebitis, hypersensitivity, bleeding tendency.

The most common side effects are hemorrhages, allergies, nausea and vomiting.

Refers to bioadditives. The price is 760 rubles. It is a combination of glucosamine and chondroitin.

Contraindications are lactation and pregnancy. Among the side effects, only allergic reactions are observed.

It is administered intramuscularly. Producer - Ellara (Russia). The price is 1885 rubles. The course is 30 injections. The active substance is chondroitin sulfate. Contraindications:

1. sensitivity to chondroitin;
2. pregnancy;
3. lactation;
4. thrombophlebitis;
5. bleeding and tendency to them.

Side effects:

1. angioedema;
2. allergies;
3. hemorrhages;

External agent with chondroitin, glucosamine and vitamin E. Relieves pain and inflammation. Apply twice or thrice a day. The gel is contraindicated in case of intolerance to the components and in case of damage to the skin. It costs from 84 to 120 rubles.

Another remedy with Russian-made chondroitin. The price is 874 rubles. Produced in the form of a solution, administered intramuscularly. The course is up to 30 injections every other day. Contraindications and side effects are the same as for other drugs with chondroitin.

Russian-made chondroprotectors are in no way inferior to foreign counterparts. The most effective are those that combine glucosamine and chondroitin.

You can also find out by watching this video what advice the doctor will give on the use of chondroprotectors.